Cartridge syringe



March 3, 1936. c. w. BARTON 2,032,559

CARTRIDGE. SYRINGE I Filed Jan. 6, 1934 2 Sheets-Sheet 1' y ,lnverzi'or I 5% J O Maich 3, c w BARTQN CARTRIDGE SYRINGE Filed Jan. 6, 1934 2 Sheets-Sheet v 2 I Inventor Patented Mar. 3, 1936 UNl'IiED STATES P T-Em; o L

I CARTRIDGE SYRINGF. Charles Walter Barton, New York, N. Y. Application January 6,1934, Serial No. 705,513

3 Claims. (01. i2s-2s4) This invention relates to a buffer solution cartridge or apparatus for the making and instilling of fresh mixtures of materials which are stable when separated and unstable when mixed.

One of the objects of the invention is to maintain the independently stable ingredient or ingredients in sealed containers guarded from external or internal contamination before, during and after the mixing operation, and at the same time to permit them to be dispensed directly from the mixing container.

A further object of the inventionv is to effect the sealed isolation of a charge of medicament which is stable when dry and relatively unstable in solution, and to permit such external manipulation of said dry charge as to cause the same to go into solution without being exposed to the atmosphere during the mixing operation. i

A further object of my invention is to provide simple and efficient means formaking fresh solutions from solid or liquid medicaments and liquid or semi-liquid solvents in a sealed dispensing container forming an integral part of my device without opening said container until immediately before use.

Another object of my invention is to enable the physician and/or patient to keep in reserve individual doses of medicaments together with their solvents each separated from the other in sealed dispensing containers, and to effect solution of the medicaments in the solvents in correct pre-determined proportions immediately be-' for use, without opening said container until the moment of administration of the medicament.

It is also a particular object of my invention to make possible the storage, in sealed dispensing containers, 'of solvents together with such medicaments as are unstable in solution and cannot now be dispensed in solution, and to provide simple and efficient means for dissolving said medicaments without opening the container, shortly before use of the solution. I

A further object of my invention is to provide a new and uncontaminated irrigation or instillationnoz zle for each irrigation or instillation, for example in thev treatment of infected parts, in order to prevent re-infection when sterilization of the syringe is not possible or convenient after each instillation.

As demonstration of a practical application of my invention 1- refer for example to the treatment of acute or chronic gonorrhea in the male, and to the prophylaxis against this infection, although it is evident that my device can be used for the treatment of many other diseases where implements of this character are indicated.

The treatment of acute and chronic gonorrhea requires, besides the periodic treatments carried out by the physician, the instillation of certain 5 antiseptic solutions by the patient himself several times daily. The prophylaxis requires instillations at a moments notice.

Heretofore it has been the practice to provide the patient with a quantity of the medicaments in dry substance, with instructions to dissolve a measured amount of the medicament in a measuredvolumeof water for each instillation. Or else, the patient obtained a limited quantity of a solution of the medicamentprepared by the druggist. These solutions then had to be drawn or poured into a syringe. in the amount required for each instillation. The medicaments usually employed in the effective treatment or for the prevention offigonorrhea' are unstable in solution; therefore it is not possible to keep on hand an' amount of such solutionssufficient for a complete course of treatment, or to keep in reserve solutions ready to use, for an indefinite period of time, to be employed for preventive irrigations at a moments notice. In the. home treatment carried out by the patient the uniformity of percentage and the accuracy of the amount of the solutions made by him were frequentlyin doubt, as was also the therapeutic efficiency of usually unstable stock solutions kept on hand for some time previous to their application. Furthermore, since the patient uses the same syringe for a complete course of treatments extending over several weeks, lack of cleanliness and insufficient or no sterilization of the syringe nozzle easily led to re-infection; thus the treatment may have been unduly prolonged.

It has been my aim-in the development of my invention to overcome the drawbacks of the method of treatment employed heretofore and to introduce novel and unique features which will make the administration of medicaments in the treatment and prophylaxis of many diseases more efficient and at the same time more convenient. These and further advantages of my invention will become apparent in'the' specification of my device and the accompanying drawings wherein-- 1 Fig. 1 is a perspective viewof a preferred form of my invention; I

Fig. 2 is a view in longitudinal cross-section of the same form of my device;

Figs. 3 and 3a are sectional and perspective views of the separate parts of a preferred form of medicament dispensing container;

Figs. 4, 4a and 4b are sectional views of my medicament dispensing container demonstrating its operation when making solutions;

Fig. 5 is a view, partly in section and partly in perspective, of a preferred form of my injector frame.

Now referring specifically to Fig. 1, the medicament dispensing cartridge or container I is shown in its position in the syringe cartridge chamber 2, the device being completely assembled and ready for making a fresh solution immediately before use.

In the longitudinal cross-section Fig. 2 the various parts are shown in their position before use,to wit: The cylindrical tube 3 containing the solvent S is sealed at one end by a movable piston 4. At its opposite end the tube 3 is sealed by the nozzle 5 having an axial recess 6 of suitable shape and size into which is fitted a hollow medicament carrier 1 of the appropriate. shape and size containing the medicament M. The ejection canall in the tip of the nozzlev I is hermetically sealed by the nipple 9. The medicament dispensing container l is held in the injector frame 2, with the flange l0 of the nozzle 5 resting on the ring ll connected by the rods l2 with the cap l3 which latter is secured to the ring by the screw-thread I. In the capl3 of the-injector frame, into the bearing I5 is fitted the slidable piston rod l8 having at one end the piston head I! and at the other end the finger rest ii.-

In Fig. 3 are shown in detail in longitudinal section the parts of which the medicament dispensing container I is composed. The tubular container 3 is a cylinder having substantially the same diameter throughout made preferably of glass, or any suitable and substantially rigid material, such as metal, bakelite and the like. The piston I is a short cylindrical body having a diameterv slightly larger than that of the tubular container 3 and is made of an elastic material such as rubber or other suitable material. When inserted into one of the openings of the tube 3 it will effectively seal it but will be susceptible to a longitudinal movement inside the tube when steady pressure is brought to bear on its outer surface at la. The nozzle- 3, made of rubber or any other elastic material suitable for the purpose, has a cylindrical plug I 9 of a diameter slightly larger than that of the tube 3 so that,

when it is inserted intothe latter it will be retained in the tube by frictional resistance and thus seal the tube at its other opening. The flange Ill rests on the edge ofthe tube 3 and prevents the nozzle, from being pushed into the tube when pressure is exerted on the nozzle from the outside. The ogival-shaped part 2| of the nozzle is perforated by a canal 3 which opens into an axial recess 6 in the body of the nozzle. The recess .6 may be round, triangular, square or of any other desired shape in cross section. The

nipple 9 has a disc-shaped top 22 and a pin-like stopper 23 of substantially the same length as, but ofslightly larger diameter than the canal 8 which it seals hermetically when inserted into it. The medicament carrier I is a tubularcontainer of substantially the same height as the axial recess 6 in the body of: the nozzle and may be any suitable shape conforming exactly to the shape and size or diameter of the axial recess 6 in the nozzle. At its one end a the medicament carrier 1 is open, at its opposite end b it is closed, and has in its wall at least one opening 0,

of any suitable shape. The friction of the compressed plug l9 of the nozzle securely holds the carrier 1 and seals the opening 0, until the dome is compressed to move the carrier 1 to its open position as shown in Figs. 4a and 4b.

Referring now to Figsni, 4a and 4b, the method of making a solution in the sealed medicament dispensing container is demonstrated as follows: In Fig. 4 is shown a cross-section of; the medica-' ment dispensing container completeand ready for use. The medicament M' is hermetically sealed in the carrier I and separated from the solvent S in the tube 3. When, as shown in Fig. 4a, pressure is exerted on the nozzle 5 by the finger resting on the disc 22 of the nipple 9, the medicament carrier 1 is forced from its seat in the recess 6 of the nozzle, suflicient to expose the opening 0 in the carrier and to liberate from the latter the medicament M which now combines with the solvent Sin the tube 3 to form a solution freshly made and ready for use. When pressure on the nozzle 5 has been released as shown in Fig. 4b, the nozzle resumes its original shape. After dissolution of the medicament has been completed, the nipple 9 is withdrawn from the canal 3 and the container is then ready for 1186.

Dissolution of the medicament as described may be carried out either before or after the dis-. pensing container has been placed in the inJector frame.

In Fig. 5 is shown a preferred form .of an injector frame, partly in cross-section andpartly in perspective view. The ring I l is provided as a seat for the flange ill of the nozzle I of the medicament dispensing container l. It has two parallel rods l2 facing each other and connected at their other end by a ring 24 screw-threaded at Ila to engage in the screw-thread Hbof the cap II. when the medicament dispensing container has been inserted into the frame and .the cap has been secured to the frame by meansof the screw-threads a and b, the device is assembled ready for use as shown in Fig. 2. 1

What I claim is:--

1. In a syringe cartridge a tube having aslidable plunger plug in one end and a compressible nozzle at the'other end, said nozzle extending at one end into said tube and outwardly. at the other end beyond the end of said tube, a cylinder extending nearly the length of said nozzle and located slidably therein, the cylinder being open at the inner end, closed at the outer or exposed end and laterallyperforated adjacent the outer or exposed end, the inner part of said cylinder H nozzleextending outward beyond said tube and holder and having therein a slidable-cylinder closed at its outer or exposed end, open at its inner end and laterally perforated near its outer or exposed end, and a removable plug mounted in said nozzle for the purpose specified.

3. A cartridge having a tube, a piston plug closing one end of said tube, a compressible stopper ping ciosing the other end of said tube and having a. nozzle and opening therein projecting beyond the tube, a removable closure for the opening in said nozzle, and a container slidably located in said stopper plug in communication at one end with said nozzle opening and the other end closed and having an opening adjacent thereto adapted to be exposed to the contents 01' said tube when said container is moved part way out 01' said plug by the compression of said projecting nozzle.

' CHARLES WALTER BARTON. 

